TTOP'S MODULAR AND VERSATILE DESIGN enables researchers to replicate human’s complex biology and simplify research procedures.
- Direct protocols' translation from conventional inserts
- Plug-and-play approach
- Real time monitoring and experimental automation
THE
PROBLEM
It is estimated that, to put a new drug on the market, are required more than $2B and 10-12 years in R&D. More than 80% of drugs that look promising in animal models fail when tested in humans.
TTOP is a modular, versatile, and user-friendly MicroPhysiolgical platform that guarantees more predictive results than conventional cell culture technologies, replicating complex human pathophysiological conditions, minimizing the controversial animal use in research.
TTOP features a cartridge-based design that is ideal for both traditional studies and advanced culture techniques.
Its patented design allows for careful management of biological samples,
enabling damage-free retrieval
for end-point analysis or reuse in subsequent treatments.”
THE
TECHNOLOGY
THE
PRODUCTS
The modularity of TTOP technology enables a transition from
conventional static in vitro modeling to
advanced culture conditions, that mimic the human dynamic microenvironment.
Moreover, it allows real time monitoring of cell growth and differentiation.
TToP versatily allow to host multiple types of biological samples.
THE
Applications
THE
PROBLEM
The drug development process is very expensive and requires very long times.
It is estimated that, to put a new drug on the market, are required more than $2B and 10-12 years in R&D. More than 80% of drugs that look promising in animal models fail when tested in humans, 60% of those failures due to a limited efficacy and another 30% due to cell/organ toxicity.
TToP is a modular, versatile, and user-friendly MicroPhysiolgical platform that guarantees more predictive results than conventional cell culture technologies, replicating complex human pathophysiological conditions, minimizing the controversial animal use in research.
TToP is a modular, versatile, and user-friendly MicroPhysiolgical platform that guarantees more predictive results than conventional cell culture technologies, replicating complex human pathophysiological conditions, minimizing the controversial animal use in research.
THE
TECHNOLOGY
TToP is based on a cartridge-based design suitable for well-established studies and for cutting-edge culture methodologies.
The patented technology enables the controlled management of the biological sample, allowing to retrieve it without damages to perform end-point analysis or to reuse it, designing sequential treatments.
The patented technology enables the controlled management of the biological sample, allowing to retrieve it without damages to perform end-point analysis or to reuse it, designing sequential treatments.
THE
PRODUCTS
TToP enables the construction of compartmental culture models, introducing a novel feature that enables easy retrieval of the biological material without damages, for end-point analysis or sequential conditioning.
The system has a cartridge-based design. In the cartridge, it is possible to host microporous polymeric membranes, or 3D structures, such as planar scaffolds or even thin tissue biopsies.
THE
Applications
TToP
versatily allow to host multiple types of biological samples.